MS-LaserLab

Welcome at the website of the MS-Laserlab! In the MS-LaserLab, we develop and implement innovative mass spectrometric methods for the characterization of proteins, protein-protein interactions, and protein aggregation, all in the context of biological function. Our goal is to probe and unravel molecular structure to understand biological processes at the molecular level. Within this theme, we have a special interest in peptide and protein aggregation, the transition from soluble native structures to insoluble organized nanostructures, in the context of neurodegenerative diseases. However, our research also extends to biopharmaceuticals, oligonucleotides, and bioengineering of smart materials.

We specialize in native ion mobility mass spectrometry, IM-MS coupled with molecular spectroscopy (infrared and UV action spectroscopy) and/or droplet-microfluidics-MS and apply and advance these methods to study large and complex biological systems. We have developed a unique platform that combines ion mobility mass spectrometry with UV photodissociation and IR action spectroscopy in a single experiment. Initially, we will use this novel approach to understand the aggregation mechanism of Parkinson’s disease in order to ultimately control and inhibit the aggregation process.

Within the Division of BioAnalytical Chemistry at the Vrije Universiteit Amsterdam, we work together on the development and application of novel, multidimensional analytics for the molecular understanding of biological and chemical processes and the elucidation of proteins, venom-toxins, biopharmaceutical and drug characteristics.